Table 1.
Study and Patient Characteristics.
| Study, Publication year | Publication type | Study design, period | Study location | Total number of patients | Number of Males | Mean age | Type of cryotherapy | Median number of cryotherapy sessions | Histology before cryotherapy | Treatments before cryotherapy | Mean BE length | Median follow up |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Canto 2015 |
Full text | Retrospective, SC, 2006-2013 | USA | 20 | 19 | 70.9 | Carbon dioxide | 4 | HGD 18 ImCA 2 |
EMR | 5.9 cm | 54 months |
| Canto 2018 |
Full text | Prospective, SC, 2015-2016 | USA | 22 | 19 | 65.5 | Nitrous oxide | 3 | LGD 7 HGD 11 ImCA 4 |
EMR | Prague C 2.2 | 20.9 months |
| Cheng 2013 |
Abstract | Retrospective, SC, 2010-2012 | USA | 52 | 41 | 66.8 | Liquid nitrogen | 6.3 | LGD 7 HGD 20 imCA 25 |
None | NR | 3 months |
| Eluri 2017 |
Abstract | Prospective, MC, 2013-2017 | USA | 67 | 63 | 68 | Liquid nitrogen | 3 | LGD 15 HGD 37 ImCA 15 |
None | NR | 11 months |
| Goldberg 2012 |
Abstract | Prospective, SC, NR | USA | 13 | 12 | 60.5 | Liquid nitrogen | 4.7 | HGD 4 LGD 5 IND 4 |
None | 3.6 cm | 45 months |
| Gosaine 2013 |
Full text | Prospective, SC, 2006-2009 | USA | 32 | 29 | 60.5 | Liquid nitrogen | 4 | HGD 32 | EMR | 3 cm | 37 months |
| Greenwald 2010 |
Full text | Prospective, MC, 2005-2007 | USA | 24 | NR | 69 | Liquid nitrogen | 4 | HGD 17 ImCA7 |
None | 4 cm | 9 months |
| Halsey 2011 |
Full text | Prospective, SC, 2006-2010 | USA | 36 | 33 | 62 | Liquid nitrogen | 4 | HGD 36 | None | 3 cm | 6.5 months |
| Johnston 2013 |
Abstract | Retrospective, SC, NR | USA | 20 | NR | NR | Liquid nitrogen | 4 | NR | NR | 5 cm | 24 months |
| Ramay 2017 | Full text | Retrospective, SC, 2006-2012 | USA | 50 | 47 | 61.9 | Liquid nitrogen | 3 | NR | EMR | 3.5cm | 36months |
| Trindade 2017 | Full text | Retrospective, MC, 2007-2015 | USA | 27 | 24 | 68 | Liquid Nitrogen | 3 | HGD 22 LGD 5 |
EMR | 3cm | 24 months |
| Thota 2018 |
Full text | Retrospective, SC, 2006-2011 | USA | 81 | 65 | 69.1 | Liquid nitrogen | 3 | LGD 11 HGD 49 ImCA 21 |
EMR | 5.2 cm | 31.8 months |
| Verbeek 2015 |
Full text | Prospective, SC, 2011 | Netherlands | 9 | NR | NR | Carbon dioxide | 2.5 | LGD 5 HGD 1 IM 4 |
EMR | 5 cm | 12 months |
| Wani 2012 |
Abstract | Prospective, SC, NR | USA | 19 | NR | NR | Liquid nitrogen | 4.5 | NR | EMR | 4.6 cm | 3 months |
BE: Barrett’s esophagus; EAC: esophageal adenocarcinoma; ImCA: intramucosal carcinoma; LGD: low grade dysplasia; HGD: high grade dysplasia; IND: indefinite for dysplasia; IM: intestinal metaplasia; EMR: endoscopic mucosal resection; APC: Argon; SC: single center; MC: multicenter; NR: not recorded.