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Representative CAPN3 isoforms generated by alternative splicing of CAPN3. Lp82, lack of exons 6, 15 and 16; Lp85, Lp82+IS3; Rt88, Lp82+IS1. IS3, insertion sequence 3; CAPN3, calpain 3; PEF, penta-EF-hand (E, E-helix; F, F-helix); NS, N-terminus; IS1, insertion sequence 1; PC1, protease core domain 1; C2L, calpain-type β-sandwich.
