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. 2021 Sep 21;97(12):e1229–e1242. doi: 10.1212/WNL.0000000000012513

Figure 3. Distribution of Fluid Biomarker Levels Across Distinct ADNC Scores.

Figure 3

A–D) Four-point semiquantitative scales (0 = absent, 1 = low, 2 = intermediate, and 3 = high) describing Thal phases of regional distribution of β-amyloid plaques (Aβ) (A), Braak stages of tau neurofibrillary tangle pathology (B), Consortium to Establish a Registry for Alzheimer's Disease (CERAD) scores for density of neuritic plaques (C), and CERAD scores for density of diffuse plaques (D). Solid black lines represent linear regression trends. Corresponding Spearman correlation coefficients are listed in Table 2. ADNC = Alzheimer disease neuropathologic change; NfL = neurofilament light; p-tau181 = tau phosphorylated at threonine 181.