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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Radiother Oncol. 2021 Feb 3;157:155–162. doi: 10.1016/j.radonc.2021.01.023

Figure 2.

Figure 2.

Assessment of cardiovascular injury of C57BL/6J mice 18 months after irradiation. (A) Representative SPECT images of the heart after sham irradiation (n=7) or 2 Gy × 25 partial-heart irradiation (n=6). Mice were injected with 99mTc-tetrofosmin immediately before imaging. No substantial decrease in regional perfusion of the myocardium was observed in either unirradiated or irradiated mice. (B) Dot plot showing Sirius red staining of fibrosis in unirradiated (n=7) and irradiated (n=6) mice. (C to E) Echocardiography measurements of fractional shortening, left ventricular end diastolic diameter (LVDd) and end systolic diameter (LVDs) in unirradiated (n=7) and irradiated (n=6) mice. Each dot represents one mouse. Data are presented as mean ± SEM. *P<0.05 by Mann-Whitney U test.