Table 4:
Common hepatobiliary autoimmune diseases in pregnancy and their treatment
| Disease | Treatment | Continue during pregnancy | Pathophysiology |
|---|---|---|---|
| Primary sclerosing cholangitis | Ursodeoxycholic acid Steroids |
Yes Yes |
Fibrous stenosis of the intra- and extra-hepatic bile ducts |
| Primary biliary cholangitis | Ursodeoxycholic acid Azathioprine Steroids |
Yes Yes Yes |
Autoimmune liver injury related to anti-mitochondrial antibodies leading to destruction of small bile ducts and cholestasis |
| Autoimmune hepatitis | Mycophenolate mofetil Azathioprine |
No Yes |
Unknown, but it is felt to be a T-cell mediated immune intolerance to the liver parenchyma; it is thought to be triggered by the environment |