Table 3. Sociodemographic and clinicopathologic features among patients with PDAC with high vs. low plasma RNLS.
| Factor | Low RNLS | High RNLS | Total | p-value |
|---|---|---|---|---|
| Sociodemographic Characteristics | ||||
| Age at Diagnosis | 68.00 (9.83) | 66.00 (9.62) | 68.00 (9.80) | 0.018 |
| Race/ethnicity | 0.236 | |||
| White | 114/120 (95.0%) | 107/120 (89.2%) | 221/240 (92.1%) | |
| Black | 5/120 (4.2%) | 10/120 (8.3%) | 15/240 (6.3%) | |
| Other | 1/120 (0.8%) | 3/120 (2.5%) | 4/240 (1.7%) | |
| Male | 71/120 (59.2%) | 75/120 (62.5%) | 146/240 (60.8%) | 0.692 |
| BMI at Diagnosis | 26.37 (5.29) | 26.34 (6.92) | 26.29 (6.04) | 0.719 |
| Albumin | 4.00 (0.50) | 4.00 (0.50) | 4.00 (0.49) | 0.237 |
| Total Protein | 7.00 (0.71) | 7.30 (0.69) | 7.10 (0.73) | 0.004 |
| Clinicopathologic Characteristics | ||||
| Perineural Invasion | 61/75 (81.3%) | 46/50 (92.0%) | 107/125 (85.6%) | 0.122 |
| Angiolymphatic Invasion | 43/74 (58.1%) | 40/50 (80.0%) | 83/124 (66.9%) | 0.012 |
| Differentiation | 0.734 | |||
| Well | 3/75 (4.0%) | 1/50 (2.0%) | 4/125 (3.2%) | |
| Moderate | 37/75 (49.3%) | 23/50 (46.0%) | 50/125 (48.0%) | |
| Poor | 35/75 (46.7%) | 26/50 (52.0%) | 61/125 (48.8%) | |
| Node Positive | 43/76 (56.6%) | 39/51 (76.5%) | 82/127 (64.6%) | 0.024 |
| HALN Positive | 3/45 (6.7%) | 8/30 (26.7%) | 11/75 (14.7%) | 0.022 |
| Tumor Size ≥ 2cm | 58/73 (79.5%) | 44/49 (89.8%) | 102/122 (83.6%) | 0.144 |
| Any Margin | 15 (19.7) | 15 (29.4) | 30 (23.6) | 0.237 |
| Whipple Characteristics | Low (n = 53) | High (n = 36) | Total (n = 89) | |
| Neck Margin | 1 (1.9) | 2 (5.6) | 3 (3.4) | 0.563 |
| Bile Duct Margin | 0 | 0 | 0 | -- |
| Anterior Circumferential Margin | 0 | 0 | 0 | -- |
| Posterior Circumferential Margin | 11 (20.8) | 6 (16.7) | 17 (19.1) | 0.785 |
| Vascular Groove | 2 (3.8) | 0 (0.0) | 2 (2.2) | 0.513 |
| Uncinate Process | 10 (18.9) | 6 (16.7) | 16 (18.0) | 1.000 |
| Duodenal | 0 (0.0) | 1 (2.8) | 1 (1.1) | 0.404 |
| Invades Duodenum | 25 (472) | 19 (52.8) | 44 (49.4) | 0.669 |
| Gastric | 0 | 0 | 0 | -- |
| Pancreatic Duct | 13 (24.5) | 13 (36.1) | 26 (29.2) | 0.248 |
| CBD | 12 (22.6) | 9 (25.7) | 21 (23.9) | 0.801 |
| Peripancreatic soft tissue | 43 (81.1) | 32 (88.9) | 75 (84.3) | 0.386 |
| Any margin | 12 (22.6) | 9 (25.0) | 21 (23.6) | 0.805 |
| Whipple | 53 (68.8) | 36 (70.6) | 89 (69.5) | 1.000 |
| Distal Pancreatectomy Characteristics | Low (n = 24) | High (n = 15) | Total (n = 39) | |
| Peripancreatic soft tissue | 16 (69.6) | 13 (86.7) | 29 (76.3) | 0.273 |
| Pancreatic | 0 | 0 | 0 | -- |
| Anterior | 1 (4.3) | 1 (6.7) | 2 (5.3) | 1.000 |
| Posterior | 2 (8.7) | 4 (26.7) | 6 (15.8) | 0.188 |
| Spleen | 0 (0.0) | 1 (6.7) | 1 (2.6) | 0.395 |
| Any Margin | 3 (13.0) | 6 (40.0) | 9 (23.7) | 0.115 |
Low RNLS is defined as RNLS ≤ 13291.15ng/ml (median of data), high RNLS defined as > 13291.15ng/ml (median of data). Total is defined as data for all patients included in the dataset. P-value column includes p-value between low and high RNLS groups.