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. 2021 Sep 23;218(11):e20210021. doi: 10.1084/jem.20210021

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© 2021 Lin et al.

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Figure 4. — Loss of IL-27 production by IECs results in uncontrolled parasite burdens during T. gondii infection. (A and B) qPCR analysis of parasite burden in small intestine (A) and liver (B) of IEC-KO, DC-KO, or Mye-KO mice (>6 mo) along with their corresponding WT littermates at day 8 after T. gondii infection. (C) FACS analysis and frequencies of Pru-tdTomato⁺ in CD45⁻EpCAM⁺ IECs from IEC-KO mice and WT littermates (>6 mo) at day 8 after T. gondii infection. Each symbol represents an individual mouse, and the bar represents the mean. Data are pooled from at least three independent experiments. Results of Student’s t test: *, P < 0.05; **, P < 0.01.