Table 2.
The IC50, Ki, and inhibition mechanism of some screened compounds.
| Compounds | IC50(mM) | Ki(mM) | Suppression mechanism | References |
|---|---|---|---|---|
| Puerarin2 | 1.23 | / | / | 11 |
| 0.010 | 15 | |||
| 0.479 | 21 | |||
| 0.012 | 22 | |||
| Oroxin A6 | 0.50 | 12 | ||
| Baicalein8 | 0.29 | |||
| Protocatechuic acid82 | / | 9.28 | Competitive inhibitor | 13 |
| 3,5-Di-O-caffeoylquinic acid57 | 0.34 | |||
| 1,5-Di-O-caffeoylquinic acid58 | 1.1 | |||
| Chlorogenic acid59 | 0.9 | Mixed inhibitor | ||
| Quercetin-3-O-(6-O-malonyl)-β-D glucopyranoside14 | 0.268 | / | / | 14 |
| Kaempferol-3-O-(6-O-malonyl)-β-D-glucopyranoside15 | 0.104 | |||
| Mirificin38 | 0.013 | 15 | ||
| Daidzin34 | >500 | |||
| Genistinc39 | >500 | |||
| Vitexin11 | 0.35 | 16 | ||
| Isovitexin12 | 1.73 | |||
| Isoorientin10 | 7.67 | |||
| Isoorientin 3'-methyl ether13 | 8.61 | |||
| Daidzein37 | 1.58 | |||
| Genistein/ | 7.66 | |||
| 3-(5-Hydroxybenzofuran-6-yl) propanoic acid94 | 1.33 | Mixed-type inhibitor | ||
| Gallic acid78 | 0.178 | / | 20 | |
| Albiforin106 | 0.100 | |||
| Paeoniforin107 | 0.102 | |||
| Liquiritin apioside50 | 0.089 | |||
| Liquiritin84 | 0.171 | |||
| Galloylpaeoniflorin/ | 0.036 | |||
| Ononin85 | 0.101 | |||
| Isoliquiritigenin/ | 0.185 | |||
| Glycyrrhizic acid/ | 0.059 | |||
| Oxypaeoniflora/ | 0.083 | |||
| Benzoylpaeoniflorin/ | 0.032 | |||
| Benzoyloxypaeoniflorin/ | 0.040 | |||
| Mudanpioside C/ | 0.083 | |||
| Paeonolide/ | 0.102 | |||
| Apiopaeonoside/ | 0.098 | |||
| Puerarin-6’’-O-xyloside33 | 0.514 | 21 | ||
| Puerarin apioside43 | 0.877 | |||
| Emodin111 | 300mg/ml | 34 | ||
| Protocatechuic aldehyde91 | 0.455 | 35 | ||
| Hydroxysafor yellow A92 | 0.498 | |||
| Tanshinone IIA108 | 1.214 | |||
| Mulberrofuran G93 | 0.018 | 36 | ||
| Kuwanon G31 | >0.2 | |||
| Kuwanon H32 | 0.010 |