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. 2021 Sep 29;16(9):e0257986. doi: 10.1371/journal.pone.0257986

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© 2021 Dutra-Tavares et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — Effects of phencyclidine treatment, nicotine history and the combined insults on adolescent mice, as assessed in the open field arena: (A) locomotor activity and (B) anxiety-like behavior. CT: Control group (♀ = 12, ♂ = 16); NIC: Nicotine-exposed group (♀ = 14, ♂ = 14); PCP: Phencyclidine-treated group (♀ = 14, ♂ = 14); PCP-NIC: Phencyclidine-treated and nicotine-exposed group (♀ = 12, ♂ = 14). Values are means ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001. ^@p < 0.05, Day 1 vs. Day 2 or Day 1 vs. Day 3 within each experimental group. ^###p < 0.001, phencyclidine-treated (PCP and PCP-NIC) vs. phencyclidine non-treated (CT and NIC) mice.