Table 2. Endocrine irAEs among examined patients.
| No | Sex/ age | Type of NSCLC1 | irAEs | CTCAE Grade [7] | Onset time (months) | Treatment | Outcome | Anti thyroid antibodies2 |
|---|---|---|---|---|---|---|---|---|
| 1 | F/64 | Adeno | Hyperthyroidism3 | 2 | 1 | Observation→ Levothyroxin | Hypothyroidism | ↑ |
| 2 | F/58 | Squamous | Hypothyroidism | 1 | 3 | Observation | Resolution | ↑ |
| 3 | F/79 | NOS | Hypophysitis | 3 | 11 | Steroids → hormonal replacement therapy (Hydrocortisone Levothyroxine) | Secondary hypothyroidism, Secondary insufficiency adrenal glands, Secondary hypogonadism | N |
| 4 | M/75 | Squamous | Hyperthyroidism | 2 | 3 | Thiamazole | Hyperthyroidism | N |
| 5 | F/65 | NOS | Hyperthyroidism3 | 2 | 1 | Observation→ Levothyroxin | Hypothyroidism | ↑ |
| 6 | M/65 | Squamous | Hyperthyroidism | 2 | 2 | Steroids4 | - | ND |
| 7 | M/81 | Squamous | Hypothyroidism | 2 | 3 | Levothyroxin | Hypothyroidism | ↑ |
| 8 | F/67 | Adeno | Hyperthyroidism3 | 1 | 1 | Observation | Resolution | ND |
| 9 | F/63 | Squamous | Hypothyroidism | 2 | 2 | Levothyroxin | Hypothyroidism | ND |
| 10 | M/54 | Squamous | Hyperthyroidism3 | 2 | 2 | Observation→ Levothyroxin | Hypothyroidism | N |
| 11 | M/66 | NOS | Hyperthyroidism3 | 2 | 1 | Observation→ Levothyroxin | Hypothyroidism | ↑ |
| 12 | M/52 | Squamous | Hyperthyroidism3 | 2 | 1 | Thiamazole→ Levothyroxin | Hypothyroidism | ↑ |
1 squamous, squamous cell carcinoma; adeno, adenocarcinoma; NOS, not otherwise specified;
2 ↑, elevated; N. negative; ND, no data
3 clinical presentation and the natural history of this disorder suggest destructive thyroiditis
4 The key indication for systemic glucocorticosteroids in this case was immunological pneumonitis.