Table 1. Pharmacokinetic profile in plasma and epithelial lining fluid of mice following a single subcutaneous dose of lefamulin or azithromycin 35 mg/kg.

	Matrix	tmax (h),	Cmax (μg/mL),	AUC0-24h (μg∙h/mL),	AUC0-24h/Dose (μg∙h/mL)/(mg/kg),
		mean	mean±SEM	mean±SEM	mean
Lefamulin	Plasma	0.50	1.33±0.18	6.25±0.93	0.18
	ELF	0.50	2.16±0.50	12.6±1.17	0.36
Azithromycin	Plasma	0.08	2.33±0.83	11.6±1.37	0.33
	ELF	0.25	2.35±1.45	26.7±5.78	0.76

AUC_0-24h = area under the curve from time 0 to 24 hours; C_max = maximum observed plasma concentration; ELF = epithelial lining fluid; t_max = time of maximum observed concentration.