Table 1. Linear mixed model shows significant increase in rate of unique variant generation in V6 in both immunosuppressed rabbits and cultured samples.

Change in unique variants in each variable region is compared to V1 for both experiments using T-Tests following Kenward-Roger’s method [29]. Significance is denoted with asterisks (0***, 0.001**, 0.01*).

Immunosuppressed rabbits (from immunocompetent vs. immunosuppressed rabbit experiment)
Region	Estimate	Std. Error	T-Value	P-Value	Significance
V2	4.00	2.81	1.42	0.16
V3	0.42	2.81	0.15	0.88
V4	-3.46	2.81	-1.23	0.22
V5	3.41	2.81	1.21	0.23
V6	23.79	2.81	8.46	2E-12	***
V7	3.93	2.81	1.40	0.17
Cultured samples (from in vivo vs. in vitro experiment)
Region	Estimate	Std. Error	T-Value	P-Value	Significance
V2	1.13	3.36	0.34	0.74
V3	5.39	3.36	1.61	0.11
V4	-3.18	3.36	-0.95	0.35
V5	9.09	3.36	2.71	0.01	**
V6	24.77	3.36	7.38	1E-9	***
V7	4.18	3.36	1.24	0.22