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. 2021 Sep 29;7(40):eabh3243. doi: 10.1126/sciadv.abh3243

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Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 6. — Seurat analysis of immune cells from (A) wtIDH1 or (B) mIDH1 primary tumor samples, shown in UMAP projection, results in various distinct clusters. (C and D) Heatmaps showing the differentially expressed genes in each cluster of (C) wtIDH1 tumor and (D) mIDH1 tumor samples. (E) Bar plots showing the relative PMN-MDSC gene signature score in each cluster of primary human samples. (F) Quantification of the tumor-infiltrating PMN-MDSCs/total immune cells calculated from scRNA-seq data. ***P < 0.001, Student’s t test.