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. 2021 Sep 29;7(40):eabj3658. doi: 10.1126/sciadv.abj3658

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Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 1. — (A and B) Photographs of normal human donor eye retina illustrating peripheral and peri-central areas (A) and geographic atrophy (GA) retina illustrating peripheral and junctional zone center (JZC) areas (B). Scale bars, 1 mm. (C and D) In situ hybridization of RPE whole mounts with Alu cDNA–specific probes in peripheral and peri-central areas of normal eyes (C) and in peripheral and JZC areas of GA eyes (D). Insets show higher magnification. Red, Alu cDNA; green, autofluorescence. Scale bars, 10 μm. (E) Northern blotting of Alu RNA and equator blotting of Alu cDNA in macular (Mac) and peripheral (Peri) RPE of human GA (n = 7) and normal (n = 4) eyes. Densitometry of the bands corresponding to Alu RNA and Alu cDNA normalized to loading control (U6) with the mean densitometry ratio of macular RPE of normal eyes set to 1.0.