Table 2. Quantitative Analysis of GluR2 and GluR1 Receptors in 3 and 8 Months Old Ts65Dn and 2N Mice Hippocampus¹.

GluR receptor subunit	GluR2					GluR1					GluR2/GluR1 ratio at 3 months	GluR2/GluR1 ratio at 8 months
Age of mice	3 months old		8 months old		3/8 months ratio	3 months old		8 months old		3/8 months ratio
Statistical data	% from 2N	P value	% from 2N	P value		% from 2N	P value	% from 2N	P value
Fascia dentata, inferior blade
Inner ML	82.4 ± 3.6	0.004	81.3 ± 8.2	0.089	1.01	89.1 ± 5.5	0.167	82.6 ± 5.7	0.054	1.08	0.92	0.98
Middle ML	80.4 ± 4.8	0.013	92.0 ± 17.1	0.337	0.88	85.7 ± 5.4	0.107	85.9 ± 5.5	0.115	1.00	0.94	1.07
Outer ML	72.6 ± 5.1	0.005	86.7 ± 18.0	0.256	0.84	83.4 ± 4.2	0.044	83.5 ± 6.6	0.065	1.00	0.87	1.04
Granular layer	84.1 ± 4.0	0.005	91.8 ± 8.8	0.257	0.92	86.4 ± 6.9	0.136	84.3 ± 10.5	0.148	1.02	0.97	1.09
Fascia dentata, superior blade
Inner ML	82.6 ± 3.5	0.001	73.8 ± 4.3	0.004	1.12	87.1 ± 6.1	0.124	85.0 ± 2.7	0.074	1.03	0.95	0.87
Middle ML	91.1 ± 4.5	0.024	75.1 ± 3.2	0.009	1.21	88.9 ± 8.4	0.196	86.8 ± 4.2	0.147	1.02	1.03	0.87
Outer ML	90.9 ± 9.3	0.098	75.9 ± 4.7	0.009	1.20	90.9 ± 9.2	0.267	103.0 ± 7.5	0.430	0.88	1.00	0.74
Granular layer	86.4 ± 2.8	0.034	90.8 ± 10.9	0.246	0.95	88.0 ± 9.4	0.137	91.8 ± 8.7	0.265	0.96	0.98	0.99
Hilus, neuropil	87.0 ± 3.0	0.005	86.2 ± 3.0	0.090	1.01	87.5 ± 5.6	0.053	76.5 ± 5.2	0.040	1.14	0.99	1.13
CA1 area of hippocampus
Stratum oriens	93.1 ± 4.8	0.074	79.0 ± 6.1	0.035	1.18	90.1 ± 2.6	0.097	90.0 ± 6.2	0.182	1.00	1.03	0.88
Stratum pyramidale	96.0 ± 5.7	0.233	80.5 ± 11.0	0.040	1.19	91.7 ± 6.4	0.221	82.4 ± 5.8	0.072	1.11	1.05	0.98
Stratum radiatum	93.3 ± 5.8	0.140	76.1 ± 3.8	0.045	1.23	87.0 ± 3.3	0.073	87.0 ± 6.3	0.100	1.00	1.07	0.87
Stratum lacunosum moleculare	85.3 ± 2.6	0.020	70.7 ± 5.6	0.007	1.21	82.4 ± 3.7	0.029	79.9 ± 4.8	0.018	1.03	1.04	0.88

¹The number of mice used was as follows: 2N/Ts65Dn = 3/3 for 3 months old and 3/4 for 8 months old. ML, molecular layer.

Bold type face represents significant difference of studied parameters.