Table 3.
Associations for multivariate Poisson models for demographic and clinical characteristics of patients with hospitalisations or death due to COVID-19 14 days or more after first vaccine dose
| Both vaccines | BNT162b2 | ChAdOx1 | |
|---|---|---|---|
| Time since first vaccination, days | |||
| 14–20 | 1 (ref) | 1 (ref) | 1 (ref) |
| 21–27 | 0·66 (0·56–0·78) | 0·73 (0·57–0·94) | 0·61 (0·49–0·76) |
| 28–34 | 0·48 (0·40–0·57) | 0·63 (0·49–0·82) | 0·37 (0·28–0·48) |
| 35–41 | 0·37 (0·30–0·45) | 0·43 (0·33–0·60) | 0·31 (0·24–0·42) |
| 42–128 | 0·23 (0·20–0·27) | 0·33 (0·27–0·42) | 0·16 (0·13–0·20) |
| Sex | |||
| Female | 1 (ref) | 1 (ref) | 1 (ref) |
| Male | 1·27 (1·13–1·43) | 1·45 (1·22–1·73) | 1·11 (0·94–1·31) |
| Age, years | |||
| 18–64 | 1 (ref) | 1 (ref) | 1 (ref) |
| 65–79 | 1·95 (1·57–2·42) | 3·73 (2·70–5·16) | 0·96 (0·71–1·29) |
| ≥80 | 4·75 (3·85–5·87) | 8·26 (6·09–11·21) | 1·87 (1·31–2·65) |
| Previous history of COVID-19 | |||
| No | 1 (ref) | 1 (ref) | 1 (ref) |
| Yes | 0·40 (0·29–0·54) | 0·42 (0·29–0·61) | 0·38 (0·21–0·70) |
| Previous history of hospitalisation* | |||
| No | 1 (ref) | 1 (ref) | 1 (ref) |
| Yes | 3·00 (2·47–3·65) | 3·14 (2·26–4·37) | 2·74 (2·14–3·50) |
| Residential care home | |||
| No | 1 (ref) | 1 (ref) | 1 (ref) |
| Yes | 1·63 (1·32–2·02) | 1·33 (1·06–1·68) | 1·36 (0·42–4·39) |
| Deprivation status | |||
| 1—Most deprived | 1·57 (1·30–1·90) | 1·31 (0·99–1·74) | 1·83 (1·41–2·38) |
| 2 | 1·40 (1·16–1·70) | 1·27 (0·96–1·68) | 1·54 (1·19–2·01) |
| 3 | 1·00 (0·81–1·22) | 1·02 (0·76–1·35) | 0·95 (0·70–1·30) |
| 4 | 1·02 (0·83–1·25) | 0·93 (0·70–1·24) | 1·13 (0·84–1·51) |
| 5—Least deprived | 1 (ref) | 1 (ref) | 1 (ref) |
| Urban rural index | |||
| 1 (Large urban areas, other urban areas, accessible small towns) | 1 (ref) | 1 (ref) | 1 (ref) |
| 2 (Remote small towns, accessible rural areas, remote rural areas) | 1·16 (0·97–1·38) | 1·15 (0·91–1·46) | 1·03 (0·79–1·35) |
| Smoking status | |||
| Non-smoker | 1 (ref) | 1 (ref) | 1·0 |
| Smoker | 1·14 (0·97–1·33) | 1·30 (1·03–1·65) | 1·00 (0·81–1·24) |
| Ex-smoker | 1·18 (1·01–1·38) | 1·23 (0·98–1·54) | 1·15 (0·93–1·41) |
| Unknown | 1·06 (0·88–1·27) | 1·02 (0·81–1·29) | 1·15 (0·83–1·58) |
| Number of risk groups† | |||
| 0 | 1 (ref) | 1 (ref) | 1 (ref) |
| 1 | 1·39 (1·13–1·71) | 1·35 (0·99–1·84) | 1·29 (0·97–1·71) |
| 2 | 2·40 (1·95–2·95) | 2·54 (1·86–3·46) | 1·91 (1·44–2·53) |
| 3 | 3·18 (2·55–3·95) | 3·11 (2·24–4·33) | 2·58 (1·92–3·48) |
| 4 | 2·90 (2·26–3·73) | 2·64 (1·83–3·82) | 2·56 (1·81–3·61) |
| ≥5 | 4·24 (3·34–5·39) | 3·70 (2·60–5·26) | 3·94 (2·82–5·50) |
| Number of previous COVID-19 tests | |||
| 0 | 1 (ref) | 1 (ref) | 1 (ref) |
| 1 | 1·83 (1·54–2·18) | 1·91 (1·44–2·54) | 1·71 (1·36–2·15) |
| 2 | 2·21 (1·77–2·77) | 2·02 (1·45–2·82) | 2·27 (1·64–3·13) |
| 3 | 2·86 (2·25–3·65) | 2·91 (2·10–4·03) | 2·09 (1·31–3·34) |
| 4–9 | 3·01 (2·47–3·67) | 2·85 (2·13–3·81) | 3·32 (2·45–4·51) |
| ≥10 | 2·14 (1·62–2·81) | 1·92 (1·34–2·75) | 3·51 (2·17–5·69) |
Data are adjusted (for age, sex, previous history of COVID-19, Scottish Index of Multiple Deprivation, urban–rural classification, number of risk groups, care home residence, number of previous COVID-19 tests [a proxy for high-risk occupational groups], smoking status, previous history of hospitalisation [admission to hospital within 4 weeks before vaccination], and time since first vaccination) RR (95% CI). RR=rate ratio.
Previous history of hospitalisation status defined as admission to hospital within 4 weeks before first dose of vaccine.
Individual QCOVID risk groups found in the appendix (pp 21–22).