Figure 4. A cellular architecture of phase-locking in biological time control.

The simplistic cartoon, guided by recent advances, describes a logic for how intrinsically cyclic biological events (e.g., centriole biogenesis or mitochondrial fission-fusion cycles) can be phase-locked by core components of the cell cycle (e.g., Wee1 or Cdk1) or the circadian clock (e.g., REV-ERBα, BMAL1, or calcineurin) to run at similar paces. Cdk: cyclin-dependent kinase.