Table 1. Description of immune and lipid measures for homozygous APOE3/3 and APOE4+ carriers for whom age and sex are available.
Values are reported as mean (standard deviation). Linear mixed effects models fit by REML were used to test for differences between groups, controlling for age, sex, current immune activation, and seasonality, with random effects for community and individual ID. Model to test age differences includes only a random effect for individual ID. Multiple test correction was conducted for models used for hypothesis-testing; False Discovery Rate (FDR) adjusted p-values are reported for these models. No. of observations is reported as: total number of observations for the main biomarker (number of unique individuals) in each model. T-statistics use Satterthwaite's method. Due to skewness of biomarkers, statistical models use transformed and scaled data for normalization, as such, estimates are reported as standardized betas (b) with standard errors (SE). Full models with covariates and 95% confidence intervals can be found in Tables 2-3 in the Supplement. See methods for transformations for each marker.
| Variables | APOE 3/3 | Apoe4+ | No. observations per model | β | SE | t-value | p-value | FDR adj p-value |
|---|---|---|---|---|---|---|---|---|
| N | 998 | 268 | – | – | – | – | – | – |
| % female | 51% | 48% | – | – | – | – | – | – |
| Age (in years) | 54 (11.5) | 54 (11.2) | 6615 (1268) | 0.007 | 0.07 | 0.106 | 0.915 | – |
| BMI (kg/m2) | 23.9 (3.4) | 24.6 (3.7) | 6224 (1263) | 0.15 | 0.06 | 2.421 | 0.016* | – |
| C-reactive protein (mg/L) | 3.7 (3.3) | 2.9 (2.6) | 1032 (907) | -0.29 | 0.08 | -3.731 | <0.001*** | <0.001*** |
| Eosinophil (mm3) | 1617 (1060) | 1375 (910) | 6129 (1259) | -0.16 | 0.04 | -3.871 | <0.001*** | <0.001*** |
| Neutrophil (mm3) | 5044 (1803) | 4816 (1697) | 6144 (1259) | -0.03 | 0.03 | -0.816 | 0.415 | 0.435 |
| Sed Rate (mm/hr) | 29.4 (19.5) | 29.7 (19.2) | 5987 (1253) | 0.06 | 0.04 | 1.334 | 0.182 | 0.217 |
| Eosin : Lymph ratio | 0.36 (0.14) | 0.33 (0.14) | 6121 (1260) | -0.14 | 0.04 | -3.197 | 0.001** | –--- |
| Leukocytes (1000/mm3) | 9.3 (2.5) | 8.8 (2.4) | 6229 (1266) | -0.08 | 0.03 | -2.281 | 0.023* | – |
| Lymphocytes (mm3) | 2590 (832) | 2565 (852) | 6136 (1260) | 0 | 0.04 | 0.104 | 0.917 | – |
| Hemoglobin (g/dL) | 13.2 (1.5) | 13.2 (1.4) | 6195 (1263) | -0.04 | 0.05 | -0.805 | 0.421 | – |
| Triglycerides (mg/dL) | 107 (51) | 114 (61) | 2633 (1174) | 0.07 | 0.06 | 1.157 | 0.248 | – |
| Total cholesterol (mg/dL) | 144 (32) | 148 (33) | 2581 (1168) | 0.15 | 0.06 | 2.594 | 0.010** | 0.021 |
| HDL cholesterol (mg/dL) | 38 (9) | 38 (9) | 2477 (1167) | 0.05 | 0.06 | 0.83 | 0.407 | – |
| LDL cholesterol (mg/dL) | 90 (32) | 93 (32) | 2390 (1154) | 0.08 | 0.06 | 1.307 | 0.192 | 0.217 |
| Oxidized LDL (U/L) | 76 (24) | 79 (23) | 1033 (907) | 0.16 | 0.08 | 1.947 | 0.052* | 0.090t |
Statistical significance is denoted as: t p<0.10; * p<0.05; ** p<0.01; *** p<0.001.