Table 2. Models evaluating the moderating effects of APOE genotype on associations between BMI and cholesterols.

Results are fixed effects estimates from mixed effects linear regressions, which include random effects for ID and community residence. In addition to age, sex, and season, a dummy variable was used as a proxy for current illness (leukocytes > 12 mm3). Results are reported as standardized betas; CI is the 95% confidence interval. All dependent variables were transformed and centered prior to analyses. APOE genotype is coded as a categorical variable, binned as individuals that are homozygous E3 (E3) versus those that have at least one copy of the E4 allele (E4).

Predictors	Total cholesterol			LDL			Oxidized LDL
	β	CI	p	β	CI	p	β	CI	p
E4 * BMI	−0.08	−0.18–0.02	0.111	−0.09	−0.19–0.00	0.061	0.02	−0.13–0.17	0.786
APOE [E4]	0.14	0.03–0.26	0.013	0.07	−0.04–0.18	0.221	0.13	−0.03–0.29	0.112
BMI	0.18	0.14–0.23	<0.001	0.2	0.15–0.25	<0.001	0.21	0.14–0.28	<0.001
Sex [women]	0.15	0.06–0.24	0.001	0.2	0.11–0.28	<0.001	0.09	−0.03–0.21	0.158
Age [in years]	0.01	0.01–0.01	<0.001	0.01	0.01–0.02	<0.001	0	−0.01–0.01	0.869
Currently ill	0.02	−0.13–0.17	0.773	−0.03	−0.18–0.13	0.744	0.15	−0.09–0.39	0.229
Season [wet]	−0.12	−0.20–−0.04	0.004	−0.29	−0.38–−0.21	<0.001	-0.28	−0.44–−0.13	<0.001
(Intercept)	−0.7	−0.94–−0.46	<0.001	−0.71	−0.95–−0.47	<0.001	0.09	−0.28–0.46	0.626
Observations	2581			2390			1032
Marginal R2	0.049			0.074			0.07