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SCFAs and gut motility. SCFAs can promote colonic enzyme tryptophan hydroxylase-1 (TPH1) expression and 5-HT production by acting on EC cells and stimulate L cells to release PYY and GLP-1 as well as mucosal mast cells to release 5-HT, which then affect gut motility indirectly. Moreover, SCFAs derived from the blood can directly activate somas of myenteric intrinsic primary afferent neurons (IPANs) to regulate motility.
