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5-HT and gut motility. 5-HT, released from ECCs or mucosal mast cells, can contribute to smooth muscle contraction or relaxation and regulate gut sensation and secretion via various receptors located on smooth muscle cells, enteric neurons, and epithelial cells, mainly including 5-HT1, 2, 3, 4, and 7 subtypes. On the other hand, serotonin transporter (SERT), predominantly expressed by all gut epithelial cells, reuptakes excessive 5-HT to terminate its physiological effects.
