Comparison 1. Autologous blood or PRP injection versus placebo injection.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1.1 Pain relief ≥ 30% or ≥ 50%	1		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1.1 6 months	1	119	Risk Ratio (M‐H, Random, 95% CI)	1.36 [1.08, 1.72]
1.2 Mean pain (VAS 0 to 10, PRTEE)	8		Mean Difference (IV, Random, 95% CI)	Subtotals only
1.2.1 to 3 weeks	1	19	Mean Difference (IV, Random, 95% CI)	2.00 [‐0.65, 4.65]
1.2.2 > 3 weeks to 6 weeks	7	570	Mean Difference (IV, Random, 95% CI)	0.26 [‐0.14, 0.65]
1.2.3 > 6 weeks to 3 months	8	523	Mean Difference (IV, Random, 95% CI)	‐0.16 [‐0.60, 0.29]
1.2.4 > 3 months to 6 months	7	387	Mean Difference (IV, Random, 95% CI)	‐0.45 [‐1.49, 0.59]
1.2.5 > 6 months to 12 months	5	241	Mean Difference (IV, Random, 95% CI)	‐0.69 [‐1.78, 0.39]
1.3 Function (DASH, MMCPIE, Roles‐Maudsley)	9		Mean Difference (IV, Random, 95% CI)	Subtotals only
1.3.1 Up to 3 weeks	1	19	Mean Difference (IV, Random, 95% CI)	12.00 [‐5.33, 29.33]
1.3.2 > 3 weeks to 6 weeks	6	473	Mean Difference (IV, Random, 95% CI)	1.30 [‐1.64, 4.25]
1.3.3 > 6 weeks to 3 months	8	502	Mean Difference (IV, Random, 95% CI)	‐1.86 [‐4.97, 1.25]
1.3.4 > 3 months to 6 months	7	379	Mean Difference (IV, Random, 95% CI)	‐1.15 [‐8.62, 6.31]
1.3.5 > 6 months to 12 months	4	203	Mean Difference (IV, Random, 95% CI)	‐5.81 [‐16.66, 5.05]
1.4 Treatment success (> 25% improvement in pain or function)	4		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.4.1 > 6 weeks to 3 months	4	372	Risk Ratio (M‐H, Random, 95% CI)	1.00 [0.83, 1.19]
1.5 Withdrawal due to AEs	1		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.5.1 Total	1	80	Risk Ratio (M‐H, Random, 95% CI)	0.32 [0.03, 2.92]
1.6 Adverse events	5		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.6.1 Total	5	425	Risk Ratio (M‐H, Random, 95% CI)	1.14 [0.76, 1.72]