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. 2021 Sep 30;2021(9):CD010951. doi: 10.1002/14651858.CD010951.pub2

Comparison 2. Autologous blood or PRP injection versus glucocorticoid injection.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
2.1 Pain relief ≥ 50% 1   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
2.1.1 6 weeks 1 38 Risk Ratio (M‐H, Random, 95% CI) 0.19 [0.07, 0.53]
2.1.2 1 year 1 38 Risk Ratio (M‐H, Random, 95% CI) 1.67 [1.03, 2.71]
2.2 Mean pain 13   Mean Difference (IV, Random, 95% CI) Subtotals only
2.2.1 Up to 3 weeks 5 280 Mean Difference (IV, Random, 95% CI) 2.06 [0.67, 3.45]
2.2.2 > 3 weeks to 6 weeks 13 707 Mean Difference (IV, Random, 95% CI) 0.99 [0.21, 1.77]
2.2.3 > 6 weeks to 3 months 11 627 Mean Difference (IV, Random, 95% CI) ‐1.15 [‐1.71, ‐0.59]
2.2.4 > 3 months to 6 months 8 427 Mean Difference (IV, Random, 95% CI) ‐1.55 [‐2.21, ‐0.90]
2.2.5 > 6 months to 1 year 4 258 Mean Difference (IV, Random, 95% CI) ‐1.59 [‐2.22, ‐0.97]
2.2.6 > 1 year 1 100 Mean Difference (IV, Random, 95% CI) ‐2.11 [‐3.19, ‐1.03]
2.3 Function (various scales) 14   Mean Difference (IV, Random, 95% CI) Subtotals only
2.3.1 Up to 3 weeks 3 170 Mean Difference (IV, Random, 95% CI) 16.46 [‐4.23, 37.15]
2.3.2 > 3 weeks to 6 weeks 13 724 Mean Difference (IV, Random, 95% CI) 6.11 [1.79, 10.44]
2.3.3 > 6 weeks to 3 months 12 635 Mean Difference (IV, Random, 95% CI) ‐10.19 [‐14.16, ‐6.21]
2.3.4 > 3 months to 6 months 7 374 Mean Difference (IV, Random, 95% CI) ‐5.07 [‐12.66, 2.52]
2.3.5 > 6 months to 1 year 4 317 Mean Difference (IV, Random, 95% CI) ‐8.94 [‐12.09, ‐5.78]
2.3.6 > 1 year 1 100 Mean Difference (IV, Random, 95% CI) ‐18.90 [‐28.27, ‐9.53]
2.4 Treatment success 7   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
2.4.1 Up to 6 weeks 5 317 Risk Ratio (M‐H, Random, 95% CI) 0.26 [0.07, 0.95]
2.4.2 > 6 weeks to 3 months 3 188 Risk Ratio (M‐H, Random, 95% CI) 1.56 [1.08, 2.26]
2.4.3 > 3 months to 6 months 3 187 Risk Ratio (M‐H, Random, 95% CI) 1.02 [0.23, 4.44]
2.4.4 > 6 months to 1 year 3 300 Risk Ratio (M‐H, Random, 95% CI) 1.61 [0.55, 4.75]
2.4.5 > 1 year 2 199 Risk Ratio (M‐H, Random, 95% CI) 1.00 [0.31, 3.16]
2.5 Adverse events 5 317 Risk Ratio (M‐H, Random, 95% CI) 1.64 [0.65, 4.12]
2.6 Grip strength 6   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
2.6.1 Up to 3 weeks 3 170 Std. Mean Difference (IV, Random, 95% CI) ‐0.52 [‐0.87, ‐0.16]
2.6.2 > 3 weeks to 6 weeks 6 348 Std. Mean Difference (IV, Random, 95% CI) ‐0.26 [‐0.68, 0.16]
2.6.3 > 6 weeks to 3 months 6 348 Std. Mean Difference (IV, Random, 95% CI) 0.56 [0.19, 0.93]
2.6.4 > 3 months to 6 months 2 68 Std. Mean Difference (IV, Random, 95% CI) 0.35 [‐0.13, 0.83]
2.6.5 > 6 months to 1 year 2 118 Std. Mean Difference (IV, Random, 95% CI) 0.66 [0.29, 1.03]