Skip to main content
. 2021 Sep 30;2021(9):CD010951. doi: 10.1002/14651858.CD010951.pub2

NCT03072381.

Study name PEAK platelet rich plasma injection treatment for chronic lateral epicondylosis
Methods Parallel 2‐arm double‐blind randomised controlled trial
Participants Inclusion criteria
  • Age 18 to 65 years

  • Chronic (> 3 months) unilateral or bilateral common extensor tendon pain

  • Clinical exam findings consistent with CLE

  • Imaging confirmation of CLE (U/S or MRI)

  • Self‐reported failure of supervised physical therapy

  • Self‐reported failure of at least 2 of the most common treatments (NSAIDs, relative rest, ice, bracing) for CLE


Exclusion criteria
  • Inability to comply with follow‐up requirements of the study

  • History of bleeding disorder, low platelet count, other haematological condition

  • Elbow pain with other possible aetiology (e.g. degenerative joint disease)

  • Currently using anticoagulation or immunosuppressive therapy

  • Anticoagulant or immunosuppressive therapy within the prior month

  • Known allergy to lidocaine

  • Self‐reported pregnancy

  • Workers' compensation injury

  • Pending litigation

  • Concurrent opioid use for pain

  • Glucocorticoid injection within past 3 months

  • Minor

Interventions Platelet‐rich plasma group
Participants will receive a single ultrasound‐guided intratendinous (common extensor tendon origin) injection of up to 3 mL of autologous PEAK platelet‐rich plasma
Glucocorticoid control group 
Participants will receive a single ultrasound‐guided intratendinous injection of approximately (may be limited by tendon/soft tissue limitations of the subject) 2 mL of 1% lidocaine + 1 mL of 40 mg Kenalog (triamcinolone hexacetonide, 40 mg/mL) at Week 0
Outcomes Primary outcome measure
  • Change in QUICK DASH upper limb disability questionnaire at 52 weeks (scale 0 to 100; higher is worse)


Secondary outcome measures
  • Ultrasound evaluation of change in pathological features

  • Evaluation of participant satisfaction with PRP therapy

Starting date March 2017
Contact information John J. Wilson, MD; MS608‐440‐6543; wilson@ortho.wisc.edu
Kenneth S. Lee, MD; 608‐263‐8183; klee2@uwhealth.org
Notes Status: recruiting
ClinicalTrials.gov (accessed 26 July 2019)