Table 1.
Clinical presentation and laboratory tests at admissiona
| Non-combined event group (n = 548) | Combined event group (n = 225) | p value | Or (95% CI) | |
|---|---|---|---|---|
| Male gender | 238/548 (43.4%) | 168/225 (74.7%) | <0.001 | 3.84 (2.72–5.42) |
| Age (y), mean ± SD | 42 ± 13 | 49 ± 11 | <0.001 | |
| A/oligosymptomatic | 110/546 (20.1%) | 9/225 (4%) | <0.001 | 0.17 (0.08–0.33) |
| Dyspnoea | 230/543 (42.4%) | 159/225 (70.7%) | <0.001 | 3.28 (2.35–4.58) |
| Tachypnoea | 44/541 (8.1%) | 94/221 (42.5%) | <0.001 | 8.36 (5.56–12.57) |
| Fatigue | 165/542 (30.4%) | 117/223 (52.5%) | <0.001 | 2.52 (1.83–3.47) |
| Anosmia | 59/532 (11.1%) | 28/221 (12.7%) | 0.537 | 1.16 (0.72–1.88) |
| Dysgeusia | 60/532 (11.3%) | 29/219 (13.2%) | 0.449 | 1.20 (0.75–1.92) |
| Sore throat | 86/532 (16.2%) | 56/222 (25.2%) | 0.004 | 1.75 (1.20–2.56) |
| Fever | 371/544 (68.2%) | 202/225 (89.8%) | <0.001 | 4.10 (2.57–6.54) |
| Cough | 302/543 (55.6%) | 170/223 (76.2%) | <0.001 | 2.56 (1.80–3.64) |
| Vomiting | 38/535 (7.1%) | 19/222 (8.6%) | 0.490 | 1.22 (0.69–2.17) |
| Diarrhoea | 73/536 (13.6%) | 41/222 (18.5%) | 0.089 | 1.44 (0.95–2.19) |
| Myalgia or arthralgia | 157/540 (29.1%) | 95/223 (42.6%) | <0.001 | 1.81 (1.31–2.50) |
| Spo2 <92% | 42/533 (7.9%) | 114/222 (51.4%) | <0.001 | 12.34 (8.19–18.60) |
| Chest X-ray abnormality | 349/515 (67.8%) | 199/214 (93.0%) | <0.001 | 6.31 (3.62–11.00) |
| Hypotension (SBP <90 mmHg) | 15/524 (2.9%) | 20/218 (9.2%) | <0.001 | 3.43 (1.72–6.83) |
| Glasgow coma score <15 | 2/514 (0.4%) | 6/200 (3.0%) | 0.003 | 7.92 (1.58–39.56) |
| Elevated D-dimer | 166/492 (33.7%) | 132/190 (69.5%) | <0.001 | 4.47 (3.12–6.41) |
| Elevated procalcitonin | 25/418 (6.0%) | 49/158 (31.0%) | <0.001 | 7.07 (4.18–11.96) |
| Elevated CRP | 312/529 (59.0%) | 195/216 (90.3%) | <0.001 | 6.46 (3.99–10.46) |
| Elevated transaminases | 120/519 (23.1%) | 111/198 (56.1%) | <0.001 | 4.24 (3.00–6.00) |
| Elevated ferritin | 92/294 (31.3%) | 115/133 (86.5%) | <0.001 | 14.03 (8.06–24.43) |
| Elevated LDH | 211/508 (41.5%) | 154/191 (80.6%) | <0.001 | 5.86 (3.93–8.74) |
| Creatinine >1.5 mg/dL | 40/529 (7.6%) | 22/219 (10%) | 0.262 | 1.37 (0.79–2.36) |
| Lymphocytes <1500 μL | 288/529 (54.4%) | 171/217 (78.8%) | <0.001 | 3.11 (2.15–4.50) |
Abbreviations: CRP, C-reactive protein; LDH, lactate dehydrogenase; OR, odds ratio; SBP, systolic blood pressure; SD, standard deviation; Spo2, oxygen saturation.
a
Univariate analysis. Risk estimations for the composite end point.