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. 2021 Aug 24;597(7878):703–708. doi: 10.1038/s41586-021-03908-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, Detection of viruses with key signature mutations in spike protein over time. The earliest detected variant with the E484K mutation was collected in mid-November 2020. The prevalence of E484K (samples with E484K/total PCR-genotyped samples) subsequently increased over time, from 1.8% between 1 and 15 December 2020 to 26.1% between 1 and 15 March 2021. Throughout late 2020 and early 2021, we identified fewer isolates with N501Y than with E484K, with a maximum of 5.9% of isolates containing N501Y in mid-February 2021. b, Distribution of different viral lineages identified by whole-genome sequencing. Within our collection of SARS-CoV-2 genomes (n = 1,507), the B.1.526 lineage rapidly increased in prevalence in early 2021, replacing the majority of other lineages (the blank space) present during this timeframe. This was followed by a steady rise in B.1.1.7 by mid-2021. The line below the x axis denotes the time period used to calculate the growth advantage of B.1.526 over other viruses that appeared earlier.