Extended Data Fig 3. Heat maps generated through supervised clustering by structure-function-based groups cluster drug sensitivity better than exon-based groups.

a, b, Heat maps supervised clustering by exon-based (a) or structure-function-based (b) groups of log (Mutant/WT) ratios from Ba/F3 cells expressing indicated mutations after 72 h of indicated drug treatment. To determine the mutant/WT ratio, IC₅₀ values for each drug and cell line were calculated and then compared to the average IC₅₀ values of Ba/F3 cells expressing WT EGFR (+10ng/ml EGF to maintain viability). Squares are representative of the median of n=3 replicates. For co-occurring mutations, the order of mutations 1, 2, and 3 were assigned arbitrarily. Groups were assigned based on structural predictions

Source data.