Fig. 1.

Time to the all-cause emergency room (ER) visit in the a ≥ 10% and b ≥ 30% dose reduction cohorts in the overall population. These are Kaplan–Meier graphs describing the time to the all-cause ER visit in the ≥ 10% and ≥ 30% dose reduction and stable dose cohorts in the overall population. The x-axis represents time in months at an interval of 4 months, and the y-axis represents the proportion of patients free of event. The median time to the all-cause ER visit was 11.2 months for both the ≥ 10% dose reduction and stable dose cohorts, with a p value of < 0.001. The median time to the all-cause ER visit was 10.2 months for the ≥ 30% dose reduction cohort and 11.1 months for the stable dose cohort, with a p value of < 0.001