Table 1.
Baseline patient’s characteristics. All measures expressed as n (%), mean (SD) or median with interquartile range (quartile 1 to quartile 3)
| Variable | Overall (n = 596) |
No PPMI (n = 125) |
PPMI (n = 471) |
p value |
|---|---|---|---|---|
| Age | 83.4 (5.5) | 83.1 (5.7) | 83.5 (5.4) | 0.420 |
| Men | 258 (43.3) | 68 (54.4) | 190 (40.3) | 0.007 |
| BMI | 25.3 (4.2) | 25.6 (4.4) | 25.2 (4.1) | 0.274 |
| NYHA | ||||
| Class I | 31 (5.2) | 7 (5.6) | 24 (5.1) | 0.012 |
| Class II | 246 (41.3) | 44 (35.2) | 202 (42.9) | |
| Class III | 280 (47.0) | 58 (46.4) | 222 (47.1) | |
| Class IV | 39 (6.5) | 16 (12.8) | 23 (4.9) | |
| EUROSCORE II | 4.4 (3.3–6.5) | 4.6 (3.4–7.0) | 4.3 (3.2–6.4) | 0.194 |
| Diabetes | 166 (27.9) | 47 (37.6) | 119 (25.3) | 0.012 |
| Previous acute coronary syndrome | 108 (18.1) | 29 (23.2) | 79 (16.8) | 0.129 |
| CAD | 267 (44.8) | 70 (56.0) | 197 (41.8) | 0.006 |
| Previous valvuloplasty | 52 (8.7) | 16 (12.8) | 36 (7.6) | 0.097 |
| Pre-TAVR creatinine (mg/dL) | 1.1 (0.9–1.4) | 1.1 (0.9–1.4) | 1.1 (0.9–1.4) | 0.914 |
| Pre-TAVR CrCl (mL/min) | 37.5 (28.6–49.6) | 41.3 (32.0–53.8) | 36.8 (27.6–48.1) | 0.012 |
| Baseline hemoglobin (mg/dL) | 12.0 (10.9–13.1) | 12.2 (11.5–13.2) | 11.9 (10.8–12.9) | 0.015 |
| Baseline NT-proBNP (ng/dL) | 3401.0 (1564.8–7788.3) | 3897.0 (2023.0–8023.0) | 3258.0 (1403.5–7672.5) | 0.252 |
| Atrial fibrillation | 205 (34.4) | 47 (37.6) | 158 (33.5) | 0.466 |
| COPD | 141 (23.7) | 36 (28.8) | 105 (22.3) | 0.160 |
| LVEF (%) | 55.0 (48.0–60.0) | 55.0 (40.0–55.0) | 55.0 (50.0–60.0) | < 0.001 |
| Maximum aortic gradient (mmHg) | 100.0 (82.0–112.0) | 96.0 (69.8–108.3) | 99.0 (80.0–112.0) | 0.052 |
| Mean aortic gradient (mmHg) | 51.5 (44.0–60.0) | 49.0 (40.0–60.0) | 51.5 (44.8 to 60.0) | 0.056 |
BMI body mass index, BNP brain natriuretic peptide, CAD coronary artery disease, COPD chronic obstructive pulmonary disease, CrCl creatinine clearance, LVEF left ventricular ejection fraction, NYHA; new york heart association, PPMI post-procedure myocardial injury, TAVR transcatheter aortic valve replacement