Table 3.

Pooled mean GAIS scores in 12-month follow-up (pooled means are given as mean with 95% confidence intervals)

	Overall	HA combined	Monophasic HA	Biphasic HA	Collagen	Mesoglow	IAL-systems	Autologous fat
2 weeks	3.21 [3.11–3.32]	3.21 [3.11–3.32]	3.28 [3.13–3.43]	3.15 [3.01–3.3]
I2	71%	71%	74%	76%
No of studies	3	3	2	2	0	0	0	0
1 month	2.21 [2.14–2.28]	2.86 [2.55–3.17]	2.9 [2.53–3.28]	2.77 [2.21–3.34]		2.08 [1.97–2.19]	2.03 [1.93–2.14]	3 [2.8–3.2]
I2	94%	0%	0%	NA		88%	86%	NA
No of studies	4	2	2	1	0	1	1	1
2 months	2.47 [2.43–2.52]	2.65 [2.58–2.71]	2.63 [2.51–2.74]	2.66 [2.58–2.74]		1.75 [1.6–1.9]	1.75 [1.61–1.89]
I2	97%	74%	0%	87%		NA	NA
No of studies	5	4	2	3	0	1	1	0
3 months	2.32 [2.21–2.44]	2.01 [1.68–2.33]		2.01 [1.68–2.33]	2.37 [2.25–2.5]
I2	90%	96%		96%	0%
No of studies	2	2	0	1	1	0	0	0
4 months	2.24 [2.2–2.29]	2.34 [2.28–2.4]	2.51 [2.39–2.63]	2.27 [2.2–2.35]		1.4 [1.23–1.57]	1.4 [1.25–1.56]
I2	98%	98%	50%	98%		NA	NA
No of studies	6	5	2	4	0	1	1	0
5 months	2.78 [2.6–2.96]
I2	NA
No of studies	1	0	0	0	0	0	0	0
6 months	2.32 [2.26–2.37]	2.35 [2.29–2.42]	2.36 [2.22–2.5]	2.35 [2.28–2.43]	2.08 [1.93–2.24]
I2	93%	95%	NA	96%	0%
No of studies	5	4	1	4	1	0	0	0
9 months	1.68 [1.52–1.83]				1.68 [1.52–1.83]
I2	0%				0%
No of studies	1	0	0	0	1	0	0	0
12 months	1.27 [1.12–1.42]				1.27 [1.12–1.42]
I2	0%				0%
No of studies	1	0	0	0	1	0	0	0

NA—not applicable