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. 2021 Sep 29;11:19296. doi: 10.1038/s41598-021-98590-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Intermittent access to a HFD induces binge-like eating with neural activation in the striatum. (A and B) The mRNA expression levels of cFos (A) and ΔFosB (B) in the caudate putamen (CPu) in binge and control mice groups. (C and D) The phosphorylation of dopamine- and cyclic-AMP–regulated phosphoprotein of molecular weight 32,000 (DARPP32) in the CPu in binge (C) and control (D) groups. (E and F) The mRNA expression levels of cFos (E) and ΔFosB (F) in the nucleus accumbens (NAc) in binge and control groups. (G and H) The phosphorylation of DARPP32 in the NAc in binge (G) and control (H) groups. All values are mean ± SEM. Statistical analyses were performed using two-way factorial analysis of variance (ANOVA) (A,B,E, and F) followed by Sidak’s post-hoc test or an unpaired t-test (C,D,G, and H). #p < 0.05 versus 0 min in the same group. *p < 0.05 versus control. See also Supplemental Table 2 for details on statistics.