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. 2021 Sep 29;11:19296. doi: 10.1038/s41598-021-98590-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Baclofen suppresses cFos and ΔFosB mRNA expression levels as well as phosphorylation of DARPP32 in the CPu. (A–C) The mRNA expression levels of cFos (A) and ΔFosB (B), and phosphorylation of dopamine- and cyclic-AMP–regulated phosphoprotein of molecular weight 32,000 (DARPP32) protein (C) in the caudate putamen (CPu) in wild-type (WT) mice of the binge group treated with baclofen and vehicle. (D–F) The mRNA expression levels of cFos (D) and ΔFosB (E), and phosphorylation of DARPP32 (F) in the nucleus accumbens (NAc) in WT mice of the binge group treated with baclofen and vehicle. All values are mean ± SEM. Statistical analyses were performed using two-way factorial analysis of variance (ANOVA) (A,B,D and E) followed by Sidak’s post-hoc test or an unpaired t test (C and F). #p < 0.05 versus 0 min in WT mice. †p < 0.05 versus 0 min in KO mice. *p < 0.05 versus WT mice. See also Supplemental Table 2 for details on statistics.