Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Sep 29;12(10):888. doi: 10.1038/s41419-021-04193-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — A Representative images of dissected tumors from nude mice transplanted with stable hsa_circ_0043280 overexpression or hsa_circ_0043280 overexpression/PAQR3 knockdown cells. B Subcutaneous tumor growth curves of mice in different treatment groups. C The mean weight of tumors upon sacrifice in the experimental groups. D Representative images of the nude mouse model of popliteal LN metastasis. The indicated CCa cells were injected into the footpads of the nude mice, and the popliteal LNs were enucleated and analyzed. Representative images of enucleated popliteal LNs (E) and histogram analysis of the LN volume (F) in the indicated cells. G Representative images of HE and IHC as indicators of LN status. Original magnification, × 40 for HE and IHC, × 100 (Red). H Quantification of popliteal LN metastasis in the indicated groups. Representative images of HE staining of the lungs (I) and the number of nodules showing lung metastasis (J) in the tail-vein injection nude mice model undergoing different treatments. Original magnification, × 20. Each experiment was performed at least three times independently. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.