Table 1.
Anthropometric, biochemical and bone characteristics of the study cohort.
| Control (N = 52) | Osteoarthritis (N = 23) | Fracture (N = 25) | ANOVA p value |
|
|---|---|---|---|---|
| Age (years) | 65.5 ± 6.8 | 69.9 ± 9.7 | 76.8 ± 8.3 (a,b) | < 0.0000 |
| Weight (kg) | 69.4 ± 11.7 | 68.7 ± 11.1 | 68.0 ± 10.6 | 0.861 |
| Height (cm) | 157.5 ± 6.6 | 157.9 ± 5.1 | 156.1 ± 4.0 | 0.495 |
| BMI (kg/m2) | 28.1 ± 4.9 | 27.5 ± 3.9 | 27.9 ± 4.1 | 0.877 |
| FN-BMD (g/cm2) | 0.780 ± 0.162 | 0.800 ± 0.141 | 0.640 ± 0.122 (b,c) | 0.0002 |
| FN T-score | − 1.175 ± 1.442 | − 0.313 ± 0.996 | − 2.457 ± 1.075 (c,d) | 0.00001 |
| FN Z-score | 0.144 ± 1.431 | 0.873 ± 1.061 | − 0.795 ± 0.770 (c,d) | 0.0005 |
| LS-BMD (g/cm2) | 0.992 ± 0.170 | 1.033 ± 0.154 | 0.922 ± 0.149 | 0.055 |
| LS T-score | − 1.216 ± 1.445 | − 0.585 ± 1.455 | − 1.794 ± 1.701 | 0.097 |
| LS Z-score | 0.377 ± 1.577 | 0.954 ± 1.472 | 0.294 ± 1.676 | 0.455 |
| CTx (ng/ml) | 0.367 ± 0.153 | 0.443 ± 0.156 | 0.659 ± 0.220 (a,b) | < 0.0000 |
| Total-ALP (U/l) | 170.7 ± 39.9 | 144.6 ± 73.0 | 176.8 ± 92.1 | 0.176 |
| 25(OH)D3 (ng/ml) | 25.9 ± 9.7 | 16.5 ± 9.2 (c) | 14.4 ± 10.9 (e) | < 0.0000 |
BMI body mass index, BMD bone mineral density, FN femoral neck, LS lumbar spine, CTx carboxy-terminal telopeptides of collagen I, ALP alkaline phosphatase, 25(OH)D3 25-hydroxycholecalciferol.
a: p < 0.0000 vs. control.
b: p < 0.01 vs. osteoarthritis.
c: p < 0.01 vs. control.
d: p < 0.0001 vs. osteoarthritis.
e: p < 0.0001 vs. control.