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. 2021 Sep 29;7:267. doi: 10.1038/s41420-021-00656-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Fe²⁺ in myocardial tissue was detected. B ROS in myocardial tissue was detected. C–E The protein expression of DNMT-1, NCOA4, FTH, GPX4, Beclin-1, and p62 in myocardial tissue was detected by western blotting. F The expression of NCOA4 in myocardial tissue was detected by IHC. Results are presented by means ± SD. n = 8 per group. ^#P < 0.05 compared with the NS group. *P < 0.05 compared with the DS group. ^※P < 0.05 compared with the I/R group.