Table 3.
HR (bmp) | LVSP (mm Hg) | +dp/dt (mm Hg/s) | dp/dt (mm Hg/s) | |
---|---|---|---|---|
NS | 351 ± 24 | 119 ± 10 | 6379 ± 575 | 4659 ± 391 |
DS | 310 ± 16a | 103 ± 10a | 5309 ± 380a | 3538 ± 341a |
10 min Before ischemia (baseline) | ||||
I/R | 356 ± 21 | 122 ± 9 | 6423 ± 559 | 4721 ± 415 |
DIR | 311 ± 14b | 105 ± 11b | 5320 ± 296b | 3578 ± 339b |
DIR + 5-aza-CdR | 315 ± 18 | 106 ± 9 | 5354 ± 408 | 3587 ± 254 |
2 h After reperfusion | ||||
I/R | 299 ± 20a,c | 98 ± 6a,c | 4619 ± 369a,c | 3179 ± 240a,c |
DIR | 226 ± 14a–c | 81 ± 7a–c | 2589 ± 213a–c | 2004 ± 182a–c |
DIR + 5-aza-CdR | 244 ± 10c,d | 90 ± 6c,d | 3626 ± 305c,d | 2798 ± 254c,d |
Results are expressed as mean ± SD, n = 8.
DIR diabetes mellitus + I/R, DIR + 5-aza-CdR diabetes mellitus + I/R + 5-aza-CdR, DS diabetes mellitus + sham, HR heart rate, I/R ischemia/reperfusion, LVSP left ventricular systolic pressure, NS normal + sham.
aP < 0.05 vs. NS group.
bP < 0.05 vs. their corresponding I/R group.
cP < 0.05 vs. their corresponding baseline.
dP < 0.05 vs. their corresponding DIR group.