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. 2021 Sep 29;11:19268. doi: 10.1038/s41598-021-98948-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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PI3K agonists attenuate the tumor suppressive effect of Tan-IIA. After the addition of 740y-p (10 µg /mL) to the system in which Tan-IIA (24 h IC50 concentration) and Cholangiocarcinoma cells were co-cultured, the tumor suppressive effect of Tan-IIA was attenuated. (A–E) The inhibitory effect of Tan-IIA on the proliferation of Cholangiocarcinoma cells decreased after the addition of 740y-p. (F–L) The ability of Tan-IIA to inhibit the invasion and migration of Cholangiocarcinoma cells was reduced after the addition of 740y-p. (M–O) The apoptosis-inducing effect of Tan-IIA on Cholangiocarcinoma cells was diminished after 740y-p was added. Compared with control, *p < 0.05; **p < 0.01; ***p < 0.001.