Table 1.
The list of proteins carrying the defined PTMs and found specifically in patients with ovarian cancer or patients with breast cancer.
| Gene | Protein | Sequence of peptide carrying PTM | PSM | Number of peptide identifications | Seq., % | B/Y |
|---|---|---|---|---|---|---|
| PTMs observed in patients with ovarian cancer (OC) | ||||||
| A1AT | Alpha-1-antitrypsin | ac(K)-QINDYVEK | 131 | 17 | 55 | 1B/8Y |
| TDTSHHDQDHPTFNac(K)ITPNLAEFAFSLYR | 131 | 17 | 55 | 0B/6Y | ||
| ALBU | Albumin | EQLac(K)AVMDDFAAFVEK | 94 | 17 | 32 | 0B/7Y |
| NYAEAac(K)DVFLGMFLYEYAR | 454 | 25 | 31 | 0B/6Y | ||
| RHPYFp(Y)APELLFFAK | 618 | 46 | 76 | 3B/6Y | ||
| VFDEac(K)PLVEEPQNLIK | 618 | 46 | 76 | 0B/5Y | ||
| APOA2 | Apolipoprotein A-II | EPCVEp(S)LVSQYFQTVTDYGK | 29 | 6 | 63 | 1B/6Y |
| CO3 | Complement C3 | ac(K)VLLDGVQNPR | 161 | 32 | 31 | 0B/5Y |
| HV307 | Ig heavy chain V-III region CAM | DDSac(K)NTLYLQMNSLR | 11 | 4 | 12 | 0B/9Y |
| IGHA 1 | Ig alpha-1 chain C region | SGNTFRPEVHLLPPPp(S)EELALNELVTLTCLAR | 90 | 13 | 63 | 0B/7Y |
| KNG1 | Kininogen-1 | Ep(T)TCSKESNEELTESCETK | 13 | 9 | 21 | 7B/9Y |
| TRFE | Serotransferrin | MDAac(K)MYLGYEYVTAIR | 145 | 19 | 30 | 0B/8Y |
| PTMs observed in patients with breast cancer (BC) | ||||||
| ALBU | Albumin | EQLac(K)AVMDDFAAFVEK | 465 | 27 | 43 | 1B/7Y |
| ac(K)VPQVSTPTLVEVSR | 465 | 27 | 43 | 0B/5Y | ||
| NYAEAac(K)DVFLGMFLYEYAR | 687 | 48 | 79 | 0B/8Y | ||
| APOA1 | Apolipoprotein A-I | QLNLac(K)LLDNWDSVTSTFSK | 43 | 16 | 73 | 4B/10Y |
| TRFE | Serotransferrin | ac(K)SASDLTWDNLK | 357 | 38 | 66 | 0B/9Y |
| MDAac(K)MYLGYEYVTAIR | 159 | 17 | 34 | 2B/8Y | ||
Bold values indicate the exact affected (modified) amino acid residue to attract readers' attention and for easier navigation.
Peptides are listed with the main accompanying mass-spectrometric characterizations: PSM—peptide spectra match (is the number of spectra matching the theoretical peptide sequence with high score); b- and y-type of fragment ions are C- and N-terminal sequential fragment ions populated after peptide (precursor ion) decay. Complete results are available in the Supplemental Materials Table S2.
Ac(K) acetylation of lysine; p(Y), p(T), p(S) phosphorylation of tyrosine, threonine and serine, correspondingly; PSM peptide spectra; Seq., % amino acids coverage for the identified peptides; b/y the number of revealed and attained b- and y-type fragment ions.