Table 3.

Functional amendments of proteins under the impact of the selected PTMs reported in the literature and observed in the present study.

Protein	Our experiment	Biological role of protein	PTM, literature data	Biological role of the allocated PTM	Refs
A1AT	ac-К25, ac-К125	Tissue protection from the hydrolytic catalytic activity	Glu-К342 и Glu-V75	The dire role of polymers aggregation is uncertain but observable	65,66
			Ox-M351 и ox-M358	Signs of oxidative stress and pro-inflammatory activity	67
			NO-C232	Regulation of apoptosis	68
			Galactosylation and Fucosylation patterns	Specific distinguishing of non-small-cell lung cancer from lung adenocarcinoma	31
			3 N-glycosylation sites	Increase outer arm fucosylation in ovarian cancer and breast cancer patients	69
			Carbamoyl-K359	Enhances autoimmune response in patients with rheumatoid arthritis	32
ALBU	ac-К545, ac-К323, ac-К343, ac-К378	Regulation of affinity binding with various low-molecular-weight ligands	Glu-C34	Reduction of affinity binding with tryptophane, bilirubin, warfarin, and diazepam	70
			NO-C34	Regulation of organic anions and metal transportation; reduction of affinity binding with fatty acids	37
			SH-C34	Marker of oxidative stress	71
APOA2	p-S9	Lipid binding and homeostasis11	N/D	N/D	72
CO3	Ac-K283	May act as pro-oncogenic factor due to positive regulation of VEGF expression level; involved in angiogenesis, organization and clearance of extracellular matrix, and cell migration12	Glc-Asn917 (α-chain); Glc-Asn63 (β-chain)	N/D	73
			p-T1009 (intact C3)	N/D	74
			Fuc-N85 and Sia-N939	Increase in α-2,6-sialic acid and in fucosylation in colorectal cancers patients	13
TRFE	Ac-K331, Ac-K453	Binding and transfer of iron ions; regulation of iron level, especially during pregnancy	High level of glycosylation of N432 and N630	Acute inflammation in pancreatic patients in advance to tumorigenesis	75
KNG1	p-T326	Regulation of blood coagulation, blood glucose level and induction of nociceptors	Non-specific glycosylation of N294	Unknown role; detected in colorectal cancer patients	13