. 2021 Sep 29;11:19365. doi: 10.1038/s41598-021-98120-7

Table 2.

Significant genes in the meta-analyses (significant threshold = 5.7E−07).

Gene	Chr	Smoking status and phenotype Combination	Average # variants across studies (range)	Discovery Stage		Replication Stage (UK BiLEVE)		Replication Stage (UK Biobank)		GTEx
Gene	Chr	Smoking status and phenotype Combination	Average # variants across studies (range)	P-value (interaction)	P-value (joint)	P-value (interaction)	P-value (joint)	P-value (interaction)	P-value (joint)	Expressed in lung
GPR126	6	Current & Ratio	18.8 (5–25)	0.40	1.9E−09	0.61	1.1E−16	0.54	1.4E−30	Yes
GPR126	6	Ever & Ratio	18.8 (5–25)	0.91	2.8E−08	0.98	1.7E−16	0.39	5.2E−29	Yes
PDE3B	11	Current & FEV₁	7.2 (4–9)	7.1E−06	2.9E−07	0.94	0.37	0.25	0.44	Yes