Table 3.
Conditional analysis of GPR126 (adjusting for a common variant rs3817928).
| Gene /variant | Smoking status and phenotype Combination | Discovery Stage | Replication Stage (UK BiLEVE) | Replication Stage (UK Biobank) | |||
|---|---|---|---|---|---|---|---|
| P-value (interaction) | P-value (joint) | P-value (interaction) | P-value (joint) | P-value (interaction) | P-value (joint) | ||
| Conditional gene-based analysis | |||||||
| GPR126 | Current & Ratio | 0.19 | 2.44E−03 | 0.52 | 3.90E−09 | 0.77 | 9.58E−17 |
| Ever & Ratio | 0.89 | 1.13E−02 | 0.97 | 4.26E−09 | 0.47 | 2.47E−16 | |
| Conditional single-variant analysis on the top signal in GPR126 | |||||||
| rs17280293 | Current & Ratio | 0.66 | 3.93E−03 | 0.46 | 3.94E−09 | 0.68 | 9.31E−17 |
| Ever & Ratio | 0.98 | 6.10E−03 | 0.97 | 3.97E−09 | 0.89 | 2.44E−16 | |