Fig. 7. Schematic of the mechanisms by which AVAN regulates antivirus innate immune responses.

(Upper) Cytoplasmic AVAN directly binds the B Box/CCD domain of TRIM25, which enhanced TRIM25- and RIG-I-mediated antiviral innate immune responses. (Below) Nuclear AVAN positively regulates the transcription of FOXO3a by associating with its promoter and inducing chromatin remodeling to promote neutrophil chemotaxis.