Table 3.

Parameters for nanocarriers and doxorubicin transport.

Parameter	Unit	Description		Value	Ref
$P_n$	$m/s$	Vascular permeability of nanocarriers	20 nm	$4.6\times {10}^{-10}$ (Tumor)	48,49
			50 nm	$7.38\times {10}^{-11}$ (Tumor)
			100 nm	$5.44\times {10}^{-12}$ (Tumor)
$D_n$	$m^2/s$	Diffusion coefficient of nanocarriers	20 nm	$7\times {10}^{-12}$ (Tumor)	48,49
			50 nm	$4.4\times {10}^{-12}$ (Tumor)
			100 nm	$2.2\times {10}^{-12}$ (Tumor)
${\sigma }_f$		Reflection coefficient	20 nm	0.043 (Tumor)	48,49
				$1$ (Normal)
			50 nm	0.227 (Tumor)
				$1$ (Normal)
			100 nm	0.634 (Tumor)
				$1$ (Normal)
$K_d$	$\mathit{min}$	Blood circulation decay constant	20 nm	1320	48,49
			50 nm	1096
			100 nm	600
$D_f$	$m^2/s$	Diffusion coefficient of free drug	$1.58\times {10}^{-10}$ (Normal)		48,49
			$3.4\times {10}^{-10}$ (Tumor)
KON	$m^3/(mole·s)$	Binding rate constant	300		48,49
KOFF	$1/s$	Unbinding rate constant	$8\times {10}^{-3}$		48,49
KINT	$1/s$	Internalization rate constant	$5\times {10}^{-5}$		48,49
φ	-	Tumor volume fraction available to drugs	$0.05$		48,49
Crec	$M$	Concentration of cell-surface receptors	$1\times {10}^{-5}$		48,49
ω	$m^3/mole$	Survival constant of cancer cells	$0.6603$		48,49