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. 2021 Sep 29;11:19305. doi: 10.1038/s41598-021-98437-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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MCC950 inhibited ox-LDL induced NLRP3 inflammasome activation in macrophages. The mRNA and protein (n = 5/group) expressions of TLR4, ASC, NLRP3, Caspase-1 in ox-LDL induced macrophages were shown on (a–c). The vitality of Caspase-1 was measured and presented on (d). The representative images and quantitation of ASC and Caspase-1 by immunofluorence staining (n = 5/group) were exhibited on (e–h). GAPDH served as an internal control. The magnification was ×200, Scale bar = 100 μm. Data were presented as mean ± SD. *P < 0.05 was considered significant, **P < 0.01.