Table 9.

Association between DHE exposure before or during the 1st trimester and the risk of major congenital malformations by categories of DHE exposure.

Characteristics	Major congenital malformation
	Yes n = 24,539	No n = 209,361	Crude RR (95% CI)	Adjusted RR (95% CI)
	n (%)
Study medication exposure during the 1st trimester of pregnancy
DHEa prior to pregnancy only	7 (0.03)	84 (0.04)	0.79 (0.33–1.89)	0.84 (0.35–2.02)
DHE prior and during pregnancy	6 (0.02)	72 (0.03)	0.69 (0.28–1.70)	0.71 (0.30–1.68)
DHE during pregnancy only	1 (0.004)	77 (0.04)	N.A	N.A

Adjusted for all variables included in Table 4.

^aDihydroergotamine.