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. 2021 Sep 16;12:736905. doi: 10.3389/fphys.2021.736905

Figure 1.

Figure 1

Effects of a single bout of exercise performed at three different intensities on peroxisome proliferator-activated receptor gamma-coactivator 1α (PGC-1α) mRNA expression and mitochondrial DNA (mtDNA) copy number in the hippocampus and on blood lactate levels. (A) Protocols for a single bout of exercise. The mice ran on a treadmill at three different intensities: low intensity (low): 10m/min for 30min; moderate intensity: 20m/min for 30min (moderate); and high intensity: the treadmill speed was initially set at 20m/min and gradually increased by 5m/min until the mice were exhausted. (B) Running distance for 30min at low- and moderate-intensity exercise groups and exhaustion at high-intensity exercise group. (C) Blood lactate levels immediately after a single bout of exercise at three different exercise intensities. (D) Time course changes in PGC-1α mRNA expression, and (E) mtDNA copy number in the hippocampus at non-exercise (Non-ex), 12, 24, 48, and 72h after three different exercise intensities (Non-ex, n=9; low, n=8–10/group; moderate, 8–10/group; high, 8–10/group). All data were presented as the mean±SD values. Data were analyzed using one-way ANOVA with Tukey’s post-hoc tests or two-way ANOVA with Bonferroni’s post-hoc tests. *p<0.05; **p<0.01; and ***p<0.001 in comparison with the non-exercise group if not otherwise indicated.