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. 2021 Sep 16;12:736905. doi: 10.3389/fphys.2021.736905

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Copyright © 2021 Park, Kim and Mikami.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of UK5099 on the hippocampal MCTs and BDNF mRNA expression after lactate administration and high-intensity exercise. Mice were injected with saline or UK5099 by I.P. injection 30min before a single bout of high-intensity exercise and lactate administration. MCT1, MCT2, and MCT4 mRNA expression in the hippocampus 12h after (A) exercise (Cont, n=10; Ex, n=9; UK5099+Ex, n=9) and (B) I.P. injection of lactate (Cont, n=9; Lac, n=9; UK5099+Lac, n=8). All data were presented as the mean±SD values. Data were analyzed using one-way ANOVA with Tukey’s post-hoc tests. ^*p<0.05; ^**p<0.01; and ^†p<0.1 in comparison with Cont group and ^##p<0.01 in comparison with Ex group.