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. 2021 Sep 16;12:736905. doi: 10.3389/fphys.2021.736905

Figure 5.

Figure 5

The effects of intra-hippocampal 1,4-dideoxy-1,4-imino-D-arabinitol (DAB) injection before high-intensity exercise on hippocampal glycogen, lactate levels, and PGC-1α, MCTs mRNA expression. (A) Experimental design: Mice were injected saline or DAB by intra-hippocampal injection 15min before a single bout high-intensity exercise by using a micro-injection pump. (B) Running distance to fatigue on a treadmill for mice administered vehicle (Ex) or DAB (DAB + Ex) before exercise. (C) Blood lactate concentrations immediately after exercise and control. (D) Glycogen levels in the hippocampus, (E) soleus muscle (F) liver, (G) lactate levels in the hippocampus, and (H) soleus muscle immediately after exercise, with vehicle (Ex) or DAB (DAB + Ex) and control (Cont, n=6; Ex, n=6; DAB + Ex, n=6). (I) PGC-1α, MCTs mRNA expression in the hippocampus 12h after a single bout of high-intensity exercise (Cont, n=6; Ex, n=7; DAB + Ex, n=7). All data were presented as the mean±SD values. Data were analyzed using one-way ANOVA with Tukey’s post-hoc tests. *p<0.05 and **p<0.01 compared to Cont group.