TABLE 1.
Regulation of m6A methylation-related enzymes in cells involved in AS.
| Atherosclerosis-associated cells | m6A regulators | Related genes | Effects of m6A regulators | References |
|---|---|---|---|---|
| Endothelial cells (ECs) | METTL14 | miR-19a/PremiR-19a | Proliferation and migration of vascular endothelial cells | Zhang et al. (2020) |
| METTL14 | FOXO | Inflammatory response of endothelial cells | Jian et al. (2020) | |
| WTAP/IGF2BP1/IGF2BP3 | DSP | Angiogenesis of endothelial cells | Wang et al. (2020b) | |
| FTO/YTHDF2 | FAK | Proliferation, migration and angiogenesis of endothelial cells | Shan et al. (2020) | |
| Macrophages (Mø) | METTL3 | has_circ_0,029,589/STAT1 | Apoptosis of macrophages/affects macrophage polarization | Guo et al. (2020) |
| Liu et al. (2019) | ||||
| FTO | NF-κB/STAT1/STAT6/PPAR-γ | Affects macrophage activation | Gu et al. (2020) | |
| YTHDF2 | P38/ERK/NF-κB/STAT1/PPAR-γ/MAP2K4/MAP4K4 | Affects macrophage activation/induction of the inflammatory response | Yu et al. (2019) | |
| Smooth muscle cells (SMCs) | METTL3 | α-SMA/SM22α/Calponin/SM-MHC/VEGF/HGF/TGF-β/GM-GSF/bFGF/SDF-1 | Smooth muscle cell differentiation | Lin et al. (2020) |
| WTAP | P16 | Inhibition of cell viability, proliferation and migration potential of VSMCs | Zhu et al. (2020) |