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. 2021 Sep 16;9:741074. doi: 10.3389/fcell.2021.741074

FIGURE 1.

FIGURE 1

MiR-29b-3p expression in 2D and 3D cultured A549 and MCF7 cells. (A) The morphology of 2D and 3D cultured A549 and MCF7 cells captured under a phase-contrast microscope. (B) Heat map of miRNAs microarray analysis in 2D and 3D cultured A549 cells 0.5 h after 5 Gy X-ray radiation. (C) Fold changes of miRNAs expression that are more than threefold between 2D and 3D cultured cells. (D) Relative miR-29b-3p expression measured by qRT-PCR at indicated time points in 2D and 3D cultured A549 and MCF7 cells after 5 Gy X-ray irradiation. U6 was used as an internal control. Ctrl, unirradiated groups. Significance was determined by unpaired t-test. *P < 0.05; **P < 0.01.